Fig. 2.

Sialidase abzymes significantly facilitate clearance of viable and apoptotic prey [polymorphonuclear (PMN) cells] by human monocyte-derived macrophages (MoMa). Prey cells were pretreated with indicated desialylating agents and co-incubated with macrophages; uneaten cells were counted afterwards. (a) Human autologous model (PMN+MoMa), treatment with sialidase abzymes from patients with systemic lupus erythematosus (SLE) blood. (b) Human allogeneic model (PMN+MoMa), treatment with sialidase-abzymes from immunized rabbits. A typical experiment (of two replicates, each including an abzyme isolated from distinct patient/rabbit) is shown.