Table 1.

Retinoic acid-related orphan receptor gamma t (RORγt) expression and encephalitogenicity of CD4 T helper cells

	RORγt expression (%)	Incidence of EAE	Mean day of onset	Maximum clinical score	Mean clinical score on day of onset
Th1 (IL-12)	5	5/6(83%)	7·2	4	2·4
Th17 (TGF-β1 + IL-6)	57	0/12(0%)	n.a.	n.a.	n.a.
Th17 (IL-6 + αIL-12/IFN-γ/IL-4)	13	9/9(100%)	6·6	6	2·2
Th cells (IL-6 + αIL-12/IFN-γ/IL-4/TGF-β)	6	4/5(80%)	6·3	4	1·8

Th1 = T helper type 1; IL = interleukin; TGF = transforming growth factor; IFN = interferon; n.a. = not applicable.