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. Author manuscript; available in PMC: 2014 Dec 9.
Published in final edited form as: Curr Opin Immunol. 2012 Jul 26;24(5):516–521. doi: 10.1016/j.coi.2012.07.003

Figure 1. A susceptibility gene can affect multiple pathways.

Figure 1

PTPN22 variants that are associated with T1D and other autoimmune diseases account for blunted signaling, as shown in plots of calcium flux for human B cells (left) and T cells (right), adapted from Rieck et al. [45]. The grey lines indicate individuals carrying the 1858T variant, demonstrating reduced BCR- and TCR-mediated calcium mobilization after stimulation with anti-IgM or anti-CD3, respectively.