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. Author manuscript; available in PMC: 2014 Dec 9.
Published in final edited form as: Curr Opin Immunol. 2012 Jul 26;24(5):516–521. doi: 10.1016/j.coi.2012.07.003

Figure 3. Classification of T1D susceptibility genes.

Figure 3

The examples discussed in the text illustrate different categories of genotype-phenotype relationships: (i) those genes that function in the same mechanistic pathway, such as CD25 and PTPN2; (ii) those genes that alter function in multiple different pathways or cells, such as PTPN22; (iii) those genetic variants that independently arise in the same gene but similarly affect function; and (iv) those that combine to establish key immunological thresholds, such as HLA and INS in thymic selection of proINS specific T cells.