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. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Nitric Oxide. 2014 Jan 7;37:41–45. doi: 10.1016/j.niox.2013.12.010

Fig. 3.

Fig. 3

Febuxostat inhibition of AO. The fractional inhibition of the AO-specific substrate DACA in human liver cytosol (0.05 mg protein/ml) exposed to various concentrations of febuxostat (0–1 mM). The DACA concentration was fixed at 6 μM and reaction progress determined by LC–MS/MS. The IC50 for febuxostat inhibition of DACA metabolism was determined to be 613 μM. Data represent the mean of at least 3 independent determinations.