Table 3B.
Pre-clinical evidence for effect of GST polymorphism on isothiocyanate efficacy
| Model | Agent used | GST polymorph | Outcome | Reference |
|---|---|---|---|---|
| Male Wistar rats | BITC | Subunit 3 & 2 | Increased | [52] |
| Rat T9 Glioma cells | AITC, BITC | GSTP | Increased marginally | [53] |
| AITC, BITC + dibutyryl cAMP | GSTP | Increased | ||
| Male ACI/N rats | BITC, BTC | GSTP | Reduced | [54] |
| Kinetic study | ITC | GSTP1-1 and M1-1 | Most efficient catalysis | [55] |
| GATM4-4 | Least efficient catalysis | |||
| Kinetic study | PEITC, BITC | GSTA1, A2, P1 | Catalyze forward and reverse reactions in a concentration dependent manner | [56] |
| Male Wistar rats | PEITC | GSTA | Increased in liver | [57] |
| GSTM | Increased in stomach and liver | |||
| GSTP | Increased on colon | |||
| Male F344 rats | PEITC | GSTP | Reduced in liver (Pre-initiation period of tumors) with reduced hyperplasia in esophagus and kidney | [58] |
| Enhanced in liver (Post-initiation period of tumors) with increased urinary bladder tumors | ||||
| RL34 cells (Rat liver epithelial) | BITC, PEITC | GSTP1 | Increased | [59] |
| RL34 cells | ITC | GSTA1/2 | Nrf2 dependent increase | [60] |
| GSTA3 | ||||
| GSTM1 | ||||
| PBMC cells | Watercress/PEITC | GSTM1-0 | Increased GPX and SOD | [61] |
| GSTM1-1 | Not increased GPX and SOD | |||
| GSTT1 | No impact | |||
| HL60 cells | ITC | GSTA (Overexpression) | Reduced efficacy | [62] |
| Male Wistar rats | ITC | GSTM | Increased in liver | [63] |
| GSTA | Increased in Liver | |||
| GSTT | Increased in kidney |