. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Pharmacogenet Genomics. 2015 Jan;25(1):30–37. doi: 10.1097/FPC.0000000000000101

Table 2.

Characteristics of the selected polymorphisms

GENE	rs number	Change/Position	Function/Association	MAF
NFκβ	rs28362491	-/ATTG ins upstream	Altered mRNA expression⁴¹	0.46
Leptin	rs7799039	A>G upstream	Influence on leptin expression⁴²	0.50
CD36	rs3211882	-/TGT intron	NA	0.41
DRG1	rs5749272	T>C downstream	NA	0.47
NGAL	rs12006030	G>C intron	NA	0.2
PPARγ	rs1801282	C>G Pro12Ala	Reduced transactivation activity²⁶	0.08
PPARγ	rs3856806	C>T His447His	Higher leptin levels⁴³	0.11
REG1A	rs10165462	T>C 5’UTR	NA	0.36
DSCR1	rs6517239	A>G intron	NA	0.14

Abbreviations: MAF: minor allele frequency; NFκβ: nuclear factor κβ; DRG1: developmentally-regulated GTP-binding protein; NGAL: neutrophil gelatinase-associated lipocalin; PPARγ: peroxisome proliferator activated receptor gamma; REG1A: regenerating gene IA DSCR1: Down syndrome critical region 1.