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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Sep 28;1846(2):485–493. doi: 10.1016/j.bbcan.2014.09.006

Figure 3. Semaphorin 5A signaling pathways in cell migration.

Figure 3

Semaphorin 5A can both promote and inhibit the migration of cells based on the intracellular pathways triggered. It is known to enhance cellular invasion via its interaction with MET receptor tyrosine kinase or by the activation of the MEK/ERK pathway. However, contrary to this it can recruit Rho-GDIα at its intracellular domains, which in turn inhibits cellular migration by disrupting the activity of Rac-1.