Table 1.

Semaphorin 5A in various cancers.

Cancer	Comparison to normal tissue	Functions	References
Gastric cancer	Up regulated	Enhances cell proliferation Decreases apoptosis Enhances cell migration and invasion	[54–56]
Glioma	Down regulated	Inhibits motility of cells by remodeling actin cytoskeleton and disruption of focal adhesions Induces astrocytic differentiation	[57, 58]
Lung cancer	Down regulated	Lower expression is associated with poor patient survival	[59]
Pancreatic cancer	Up regulated	Enhances tumorigenicity Increases metastasis Induces angiogenesis Acts as a cell adhesion molecule and causes the formation of homotypic aggregates	[3, 37, 51–53]
Melanoma	_	Expression observed	[50]
Prostate Cancer	Up regulated	Enhances metastatic progression	[37]