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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Biomed Inform. 2014 Jul 19;52:293–310. doi: 10.1016/j.jbi.2014.07.011

Table 2.

The most frequent predicate paths in inferred discovery patterns.

Double/triple-predicate Example
INTERACTS_WITH
CAUSES-INV
Dipyridamole INTERACTS_WITH nitric oxide
Bradycardia CAUSES-INV nitric oxide
ASSOCIATED_WITH
COEXISTS_WITH
Rosiglitazone COEXISTS_WITH apolipoprotein a-ii
Apolipoprotein a-ii ASSOCIATED_WITH myocardial infarction
COMPARED_WITH
CAUSES-INV
Bisoprolol COMPARED_WITH metoprolol
Hypotension CAUSES-INV metoprolol
ASSOCIATED_WITH
INTERACTS_WITH
Rosiglitazone INTERACTS_WITH triglycerides
Triglycerides ASSOCIATED_WITH myocardial infarction
ISA
CAUSES-INV
Naproxen ISA calcineurin inhibitor
Toxic nephropathy CAUSES-INV calcineurin inhibitor
INTERACTS_WITH
INTERACTS_WITH
ASSOCIATED_WITH
Rosiglitazone INTERACTS_WITH lyrm1
Lyrm1 INTERACTS_WITH fatty acids, nonesterified
Fatty acides, nonesterified ASSOCIATED_WITH myocardial infarction
INTERACTS_WITH
ASSOCIATED_WITH
COEXISTS_WITH
Rosiglitazone INTERACTS_WITH glycerol-3-phosphate dehydrogenase
Glycerol-3-phosphate dehydrogenase COEXISTS_WITH succinate dehydrogenase
Succinate dehydrogenase ASSOCIATED_WITH myocardial infarction
COMPARED_WITH
INTERACTS_WITH
ASSOCIATED_WITH
Rosiglitazone COMPARED_WITH glycerophosphates
Glycerophosphates INTERACTS_WITH low-density lipoproteins
Low-density lipoproteins ASSOCIATED_WITH myocardial infarction
COMPARED_WITH
COEXISTS_WITH
ASSOCIATED_WITH
Rosiglitazone COMPARED_WITH gw 501516
Gw 501516 OEXISTS_WITH high-density lipoprotein cholesterol
High-density lipoprotein cholesterol ASSOCIATED_WITH myocardial infarction