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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Biomed Inform. 2014 Jul 19;52:293–310. doi: 10.1016/j.jbi.2014.07.011

Table 6.

Some example predications for possible mechanism of rosiglitazone causing myocardial infarction.

Middle term “LDL cholesterol lipoprotein”; 123 unique predication pathways;

  • rosiglitazone INTERACTS_WITH apolipoproteins_b [114,115] INTERACTS_WITH ldl_cholesterol_lipoproteins [116] ASSOCIATED_WITH myocardial_infarction [110]

  • rosiglitazone INTERACTS_WITH paraoxonase_1 [117] INTERACTS_WITH ldl_cholesterol_lipoproteins [118] ASSOCIATED_WITH myocardial_infarction [119]

Middle term “triglyceride”; 1515 unique predication pathways;

  • rosiglitazone COEXISTS_WITH triglycerides [110] ASSOCIATED_WITH myocardial_infarction [120–124]

  • rosiglitazone INTERACTS_WITH triglycerides [125,126] ASSOCIATED_WITH myocardial_infarction

  • rosiglitazone INTERACTS_WITH glycerol-3-phosphate_dehydrogenase [127] COEXISTS_WITH triglycerides [128] ASSOCIATED_WITH myocardial_infarction

Middle term “ppar_gamma”; 992 unique predication pathways; for example:

  • rosiglitazone COEXISTS_WITH ppar_gamma [129–132] ASSOCIATED_WITH myocardial_infarction [133]

  • rosiglitazone INTERACTS_WITH ppar_gamma [134–138] ASSOCIATED_WITH myocardial_infarction

  • rosiglitazone INTERACTS_WITH glycerol-3-phosphate_dehydrogenase [127] COEXISTS_WITH ppar_gamma [139] ASSOCIATED_WITH myocardial_infarction

  • rosiglitazone INTERACTS_WITH glycerol-3-phosphate_dehydrogenase INTERACTS_WITH ppar_gamma [140] ASSOCIATED_WITH myocardial_infarction

  • rosiglitazone INTERACTS_WITH resistin [141] INTERACTS_WITH ppar_gamma [142] ASSOCIATED_WITH myocardial_infarction