Table 2.

Neurocognitive Endophenotypes (n=1560)

Traits	Heritability (h2, p value)	Age (β̂, p value)	Sex (β̂, p value)	Schizophrenia Relatedness (β̂, p value)	ERV
Sematic Fluency	0.357, 8×1016	0.018, 1×1011	0.040, 6×101	0.820, 2×101	0.305
Verbal Fluency	0.462, 1×1025	0.017, 1×1010	0.115, 9×102	1.340, 3×102	0.498
Digit Symbol	0.514, 4×1027	0.043, 2×1098	0.142, 5×103	1.590, 1×103	0.591
Trails A	0.298, 1×1011	0.029, 2×1034	0.325, 2×107	0.998, 5×102	0.371
IP CPT Hits	0.246, 5×107	0.011, 1×104	0.089, 2×101	0.767, 2×101	0.285
Digit Span Forward	0.499, 2×1028	0.023, 1×1021	0.072, 3×101	0.366, 5×101	0.136
Digit Span Backward	0.394, 8×1019	0.020, 1×1014	0.014, 8×101	1.296, 3×102	0.481
Letter Number	0.486, 2×1028	0.030, 8×1037	0.115, 6×102	1.468, 1×102	0.545
PCET Categories	0.092, 7×103	0.013, 5×107	0.061, 4×101	0.982, 3×102	0.126
SDRT Correct	0.277, 6×1010	0.010, 1×104	0.137, 5×102	0.003, 1×100	0.001
Trails B	0.453, 2×1023	0.024, 3×1020	0.220, 7×104	1.448, 1×102	0.538
CVLT Learning	0.394, 2×1017	0.022, 1×1019	0.576, 3×1019	0.196, 7×101	0.073
CVLT Delay	0.375, 5×1018	0.018, 5×1014	0.500, 2×1014	0.442, 4×101	0.164
CVLT Recognition	0.302, 2×1012	0.020, 9×1019	0.356, 9×109	0.865, 1×101	0.321
Facial Memory	0.419, 5×1021	0.013, 4×107	0.236, 5×104	0.884, 1×101	0.201
Facial Memory Delay	0.445, 6×1019	0.014, 7×108	0.277, 5×105	1.481, 5×103	0.550
Penn Emotion	0.264, 9×1010	0.026, 6×1026	0.183, 4×103	1.607, 2×103	0.516
Matrix Reasoning	0.482, 2×1028	0.034, 1×1052	0.011, 9×101	1.203, 3×102	0.447
Vocabulary	0.762, 1×1056	0.011, 6×105	0.012, 9×101	1.587, 3×102	0.589
WASI IQ	0.714, 6×1053	0.011, 2×105	0.010, 9×101	1.370, 6×102	0.509

IP-CPT Identical Pairs Continues Performance Test; PCET Penn Conditional Exclusion Test; SDRT Spatial Delayed Response Task; CVLT California Verbal Learning Test; ERV estimates assume an illness prevalence of 1%; Bolded estimates significant after correction for multiple testing (FDR=0.05).