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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Dev Biol. 2014 Oct 14;396(2):183–200. doi: 10.1016/j.ydbio.2014.08.038

Figure 10. prkcι/ζ are required for the establishment and maintenance of epithelial identity during nephron tubulogenesis in the zebrafish pronephros.

Figure 10

(A) During normal development, prkcι/ζ play an essential function in polarity establishment when mesenchymal renal progenitors undergo a MET and concerted tubulogenesis to become epithelial cells and form the pronephros. When pronephros tubule epithelial identity is established, the activity of prkcι/ζ represses pax2a expression (either directly or indirectly) to maintain normal gene expression. (B) In the absence of prkcι/ζ, polarity is not properly established during MET. Further, pronephros cells in prkcι/ζ deficient embryos ectopically express pax2a, which leads (directly or indirectly) to misexpression of genes that include wt1a, wt1b, and podxl.