Fig. 2.

Modelling transcriptional regulatory networks in haematopoiesis. Activating interactions are shown as blue arrows, repressing interactions in red. (a) Cross-antagonism between Gata1 and Pu.1 determining erythroid–myeloid lineage fate. (b) The HSC triad composed of Fli1, Gata2, and Scl. Positive auto-regulatory activity between the three constituent factors maintains a bistable network. (c) Regulatory network based on ten TF ChIPSeq, illustrating interactions between constituent members of Scl/Lyl1/Lmo2/Gata2/Runx1/Erg/Fli1 heptad. The predicted–and subsequently validated–negative regulation of Fli1 by Gata1 is shown by a dashed line.