Table 1.

Parameters derived from GABA concentration–response curves at wild type and mutant RDL receptors.

Mutant	GABA
	pEC50 (M)	EC50 (μM)	nH	n
Wild type	5.26 ± 0.11	5.9	1.6 ± 0.5	7
N-7′H	5.30 ± 0.05	5.0	2.5 ± 0.5	7
T6′M	6.00 ± 0.04*	1.0	1.4 ± 0.2	8
A20″S	5.36 ± 0.07	4.3	1.6 ± 0.4	6
A21′Q	5.33 ± 0.07	4.7	1.9 ± 0.4	6
4M2	5.89 ± 0.10*	1.3	1.0 ± 0.3	6

Data = mean ± SEM; * significantly different to WT; one-way ANOVA, p < 0.01.