Table 2.

Picrotoxin potency at wild type and mutant RDL receptors.

Mutant	pIC50 (M)	IC50 (nM)	n
Wild type	6.75 ± 0.22	180	4
N-7′H	6.25 ± 0.64	560	3
T6′M	NI		6
A20′S	7.33 ± 0.13	46	4
A21′Q	6.45 ± 0.25	360	5
4M2	NI		6

Data = mean ± SEM; NI = no inhibition at 100 μM.