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The M. tuberculosis disseminates, grows, and survives in bone marrow (BM) during early and chronic infection. Mice were infected with 82 ± 52 virulent M. tuberculosis Erdman bacilli by aerosol. At the indicated time points, viable M. tuberculosis CFUs were recovered from the lungs (A) and BM (B). Data are combined from two independent experiments each with four to six mice per time point (n = 8 to 12 mice) and shown as means ± SEM.
