Table 4.
Firing rates of principal neurons in the subiculum, CA1, CA3, and dentate gyrus during different brain states preictally
| Subiculum | CA1 | CA3 | Dentate gyrus | |
|---|---|---|---|---|
| Awake-theta | ||||
| n (seizures) | 9 | 10 | 0 | 2 |
| Baseline (Hz) | 1.71 | 0.33 | — | 1.50 |
| Peak preictal (Hz)* | 3.05 | 0.26 | — | 0.33 |
| Preictal/baseline | 1.78** | 0.77 | — | 0.22 |
| Awake-non-theta | ||||
| n (seizures) | 209 | 149 | 26 | 85 |
| Baseline (Hz) | 1.78*** | 0.54 | 0.31 | 0.87 |
| Peak preictal (Hz) | 2.73 | 0.68 | 0.54 | 1.04 |
| Preictal/baseline | 1.54** | 1.24** | 1.77** | 1.19 |
| REM sleep | ||||
| n (seizures) | 116 | 146 | 5 | 16 |
| Baseline (Hz) | 1.57 | 0.42 | 0.67*** | 0.45 |
| Peak preictal (Hz) | 2.65 | 0.58 | 0.43 | 1.11 |
| Preictal/baseline | 1.69** | 1.38** | 0.64 | 2.47** |
| Non-REM sleep | ||||
| n (seizures) | 405 | 393 | 248 | 491 |
| Baseline (Hz) | 1.32 | 0.49 | 0.28 | 0.78 |
| Peak preictal (Hz) | 2.13 | 0.66 | 0.29 | 1.55 |
| Preictal/baseline | 1.62** | 1.34** | 1.05 | 1.99** |
*Firing rate of last or second to last (in CA1) 30-s-duration bin before seizure onset.
**Peak preictal firing rate >3 SDs of baseline firing rate.
***Versus non-REM sleep (p < 0.05, ANOVA with Dunn's test).