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. 2014 Dec 10;34(50):16809–16820. doi: 10.1523/JNEUROSCI.1711-14.2014

Figure 8.

Figure 8.

Loss of Rax function leads to loss of both Lhx2 and tanycyte marker expression. Cre-induced GFP reporter expression in Foxd1-Cre;tmRtmG mice shows broad and selective labeling of cells in hypothalamus and prethalamus of adult mice (A–C). D, Schematic representation of Foxd1-Cre activity in the hypothalamus, adapted from Shimogori et al. (2010). E–J, Embryonic deletion of Rax (Foxd1-Cre;Raxlox/lox) eliminates Lhx2 expression and blocks tanycyte development (E, F), as can be seen by the corresponding loss of Rax and Gpr50 expression (G–J). AH, Anterior hypothalamus; ArcN, arcuate nucleus; CGE, caudal ganglionic eminence; DMH, dorsomedial hypothalamic nucleus; DTh, dorsal thalamus; Hy, hypothalamus; LH, lateral hypothalamus; MB, mamillary body; ME, median eminence; ON, optic nerve; PrTh, prethalamus; RetN, thalamic reticular nucleus; SN, substantia nigra; VMH, ventromedial hypothalamic nucleus; ZI, zona incerta; 3V, third cerebral ventricle. Scale bars: A–C, 500 μm; E–J, 200 μm.