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Biological regulations of hERG in nucleus and at ER. Transcription of the hERG channel (KCNH2 gene) is under the regulation of transcription factor Sp1 and the NMD mechanism. Hsc70 and Hsp70 at ER are responsible for early folding of hERG while Hsp90 in the cytoplasm is responsible for late folding. Hop, DNAJA2, and FKBP38 assist hERG release from Hsc70. Hop and FKBP38 aid hERG to recruit Hsp90 for its maturation. Hsp40 promotes degradation of hERG in the proteasome.
