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. Author manuscript; available in PMC: 2014 Dec 10.
Published in final edited form as: Macromol Biosci. 2013 Nov 27;13(12):1700–1710. doi: 10.1002/mabi.201300323

Figure 3.

Figure 3

Effect of base content on pre-loaded and lysozyme-loaded microparticle morphology. Four PLGA formulations with differing theoretical loading of base were created and loading in lysozyme solution was conducted at 4°C for 72h before healing at 42°C for 46h. SEM images were taken before (A–D) and after closing (E–H). Formulations used trehalose in PBS (pH 7.4) in the inner water phase with varying amounts of theoretical loading of MgCO3 (w/w): A,E) 0%, B,F) 1.5%, C,G) 4.3%, and D,H) 11.0%. White scale bars = 10 μm. See Fig. S4 for enlarged version.