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. 2014 Jul 1;2:14011. doi: 10.1038/boneres.2014.11

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Copyright © 2014 Sichuan University

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Effects of overexpressed human hnRNPC1 and C2 on VDR-mediated gene transcription in human and mouse osteoblast-like cells. Effect of overexpression of human hnRNPC1 (C1) and/or human hnRNPC2 (C2) on 1,25(OH)₂D-induction of the vitamin D-target genes CYP24A1/Cyp24a1 and DDIT4/Ddit4 in (a) mouse MC3T3 osteoblastic cells and (b) human MG-63 osteoblastic cells. Cells were treated with or without 10 nmol⋅L⁻¹ 1,25(OH)₂D for 6 h, 24 h post transfection with either empty vector (c), C1, C2 or C1 and C2 (C1/C2). Data show mean±s.d. (n=3 separate cultures) fold-change in mRNA expression for CYP24A1/Cyp24a1 and DDIT4/Ddit4 for each transfected cell type following treatment with 1,25(OH)₂D relative to vehicle-treated control cells. ***P<0.001, statistically different from empty vector controls (C), **P<0.01, statistically different from C.