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. 2014 Nov 30;12:76. doi: 10.1186/s12964-014-0076-4

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© Sun et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Brachyury is induced specifically in the degenerated tubular epithelia of the fibrotic kidney. (A) Immunohistochemical analysis shows inverse correlation of TGF-β1, Brachyury, Snail, Slug and E-cadherin in IgA Nephropathy and normal renal biopsy samples from patients. TGF-β1,Brachyury, Slug, Snail-negative/E-cadherin preserved case. TGF-β1,Brachyury,Slug, Snail-positve/E-cadherin reduced case. Original magnification × 400. (B) Correlation plots of tubulointerstitial expression of active Brachyury and tubulointerstitial fibrosis. Scatter plot with fitted value intervals for percent tubular expression of Brachyury and tubulointerstitial fibrosis.