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. 2014 Aug 22;15(1):283. doi: 10.1186/1471-2105-15-283

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© Jacobs et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Relative bias of the target concentration estimates under theoretical assumptions and misclassification. The relative bias is calculated as for 1000 simulated experiments of 8 replicates without any additional sources of variation. As results are relative to the true concentration λ, the precision of different dilutions of the same sample can be assessed on the same scale. Results were plotted for different misclassification probabilities (FPR, FNR) with FPR = false positive rate = 1-specificity and FNR = false negative rate = 1-sensitivity. False positives have considerable influence on the estimates for low concentrations, while false negatives substantially influence the results for highly concentrated samples.

Inline graphic — Relative bias of the target concentration estimates under theoretical assumptions and misclassification. The relative bias is calculated as for 1000 simulated experiments of 8 replicates without any additional sources of variation. As results are relative to the true concentration λ, the precision of different dilutions of the same sample can be assessed on the same scale. Results were plotted for different misclassification probabilities (FPR, FNR) with FPR = false positive rate = 1-specificity and FNR = false negative rate = 1-sensitivity. False positives have considerable influence on the estimates for low concentrations, while false negatives substantially influence the results for highly concentrated samples.