Table 3.

Factors associated with actuarial risk of developing BM for patients with resectable SCLC

Factors	Univariate analysis				Multivariate analysis
	1y	3y	3y	p	HR	95% CI	p
Gender
Male	14.3	23.0
Female	12.0	23.6	0.04	0.906
Age, years
<65	14.5	22.4
≥65	12.0	26.3	0.063	0.802
KPS score
≥80	10.6	17.3
<80	16.0	31.5	1.207	0.272
Smoking status
Positive	15.9	24.7
Negative	11.2	20.9	0.341	0.559
P-stage
I	3.1	9.7
II	15.4	18.5
III	18.8	35.4	8.621	0.013	2.013	1.135 ~ 3.569	0.017
LVI
Yes	30.8	39.9
No	9.8	17.5	8.943	0.003	1.924	1.002 ~ 3.291	0.039
PORT
Yes	17.6	33.5
No	13.2	21.3	3.351	0.067	0.825	0.329 ~ 2.064	0.680
Cycle of ChT
<4	10.0	17.5
≥4	14.5	24.2	0.240	0.624

Abbreviations: SCLC = small cell lung cancer; 1y = actuarial risk of developing BM at 1 year; 3y = actuarial risk of developing BM at 3 years; HR = hazard ratio; CI = confidence interval; KPS = Karnofsky performance status; P-stage = pathologic stage; LVI = lymphovascular invasion; PORT = postoperative radiotherapy; ChT = chemotherapy.