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. 2014 Nov 26;12:326. doi: 10.1186/s12967-014-0326-7

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© Chen et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparisons of berberine and its derivatives on activation of MAPK signaling pathways. Cells were pretreated with berberine or dhBBR, or Di-MeBBR for 1 h, followed by incubation with oxLDL for 1, 3, and 6 h. Nuclear fractions were isolated, nuclear NFκB p65 and phospho-p65 were measured by Western blotting. (A, C) Effects of oxLDL on nuclear translocation of NFκB p65 and phospho-p65 expression. (B, D, D) Berberine and its derivatives (dhBBR, di-MeBBR) on nuclear translocation of NFκB p65 and phospho-p65 expression. Lamin B and β-Actin was used for protein level normalization. *P < 0.05 vs. BBR group. ^# P < 0.05 vs. 0 h (C) or untreated control group (D, E).