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. Author manuscript; available in PMC: 2014 Dec 10.
Published in final edited form as: J Proteome Res. 2010 Oct 1;9(10):5445–5460. doi: 10.1021/pr100678k

Figure 5.

Figure 5

Cdc7 depletion protein–protein network. Network association analysis of altered proteins was created with STRING software and viewed in Cytoscape. All 315 significantly altered proteins were uploaded with an Interaction Confidence Score of ≥0.7, resulting in 175 nodes and 894 edges. Nodes are colored by fold change and are linked by edges that represent types of interaction evidence. The top six MCODE clusters of densely interconnected regions are circled and labeled according to the most enriched GOSlim term for that cluster of proteins. MCODE scores for each cluster, GO term identification number (GO-ID), annotation name, significance of GO term enrichment (corr p-value), and number of molecules within each cluster that match the term (x) are shown in the table below. Further information for each protein node can be found in Supplementary Table S1.