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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Exp Neurol. 2014 Oct 22;263:132–140. doi: 10.1016/j.expneurol.2014.10.007

Figure 6.

Figure 6

The time-course of the vascular remodeling response is independent of hypoxic dose. Mice were exposed to normoxia or hypoxic levels of 8% or 13% O2 for 7 days or 14 days and then analyzed by CD31/Ki67 dual-IF to define the number of proliferating endothelial cells (A) or by CD31/fibronectin IF to determine changes in vascular fibronectin expression (B). All experiments were performed with four different animals per condition, and the results expressed either as the mean ± SEM of dual-positive cells (A) or as the mean ± SEM of the % change compared to normoxic conditions (B). Note that at both levels of hypoxia, endothelial cell proliferation and level of fibronectin expression both peaked at the 7 day time-point, but had returned to baseline levels after 14 days. * P < 0.05, ** P < 0.01.