Fig. 1. A high fat diet rescues the metabolic phenotype of Csbm/m mice.
(A) Body weights of WT and Csbm/m mice on various diets; SD: Standard diet; HFD: High fat diet; Resv: resveratrol supplemented standard diet; CR: Caloric restricted (n=12–14, mean ± SEM). (B) Feeding efficiency shown by weight gain per food intake (n=12–14, mean ± SEM). (C) Whole body oxygen consumption over 72 hours (n=12–14, mean ± SEM). (D) Respiratory exchange rates (n=12–14, mean ± SEM). (E) Heat production (n=12–14, mean ± SEM). (F) Oral glucose tolerance tests performed after 3 hour fasting (n=5–9, mean ± SEM). (G) Insulin levels after 3 hours fasting (n=7–11, mean ± SEM). (H) Glucose levels after 3 hours fast (n=5–9, mean ± SEM). (I) Representative images of liver histology stained with hematoxylin and eosin. (J) Representative images of scanning electron microscopy of the sinusoidal endothelium (triangle: fenestration example, highlighted area: sieve plate). (K) Quantification of the fenestration diameter of the liver sinusoid (n=4–6000 from 3 mice in each group, mean ± SD). (L) The porosity of the liver using the diameter measured in (K) and the total surface area of the endothelium (n=3, mean ± SEM). See figure S1 for further information.