Table 1.
Factor | Outcome | Reference |
---|---|---|
BMP-4 (mRNA) | Acceleration of expression of BMP-4 when compression applied | Kim et al. (65)a |
TGF-β1 (mRNA) | Increased and sustained expression of TGF-β1 when compression applied | Kim et al. (65)a |
Osteonectin (mRNA) | Sustained expression of osteonectin up to 3 weeks post-compression in the accordion group | Kim et al. (65)a |
VEGF (protein) | Increased expression of VEGF in the compression group | Mori et al. (66)b |
DO, distraction osteogenesis; BMP, bone morphogenic protein; VEGF, vascular endothelial growth factor; TGF-β1, transforming growth factor beta.
aControl group (distraction of 1 mm/day for 8 days) and experimental group (distraction of 1 mm/day for 10 days followed by a 3-day latency period after which they compressed 1 mm/day for 2 days) – rabbit mandibular DO.
bControl group (distraction of 0.7 mm/day for 14 days) and experimental group (distraction of 0.7 mm/day for 14 days then compression of 0.7 mm/day for 3 days) – rabbit tibial DO.