Table 3.
Paired changes in microbial translocation and inflammation biomarkers over 12 weeks of ART
| Inflammation biomarkers (12 week change) | |||
|---|---|---|---|
| Microbial biomarkers (12 week change) | C-reactive protein | Soluble CD163 | TNF-α receptor 1 |
| Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | |
| p-value; model size | p-value; model size | p-value; model size | |
| Lipopolysaccharide binding protein | −19 (−72, 33) | 13 (−510, 536) | 757 (−1256, 2769) |
| p = 0.45; n = 20 | p = 0.96; n = 20 | p = 0.44; n = 20 | |
| Endotoxin core IgM antibody | −18 (−61, 25) | 436 (72, 800) | −74 (−1628, 1480) |
| p = 0.38; n = 19 | p = 0.02; n = 19 | p = 0.92; n = 30 | |
| Endotoxin core IgG antibody | −1.2 (−34, 31) | 168 (−86, 423) | −500 (−1413, 412) |
| p = 0.94; n = 17 | p = 0.18; n = 17 | p = 0.26; n = 18 | |
| Soluble CD14 | 38 (7, 69) | 697 (183, 1212) | 553 (−208, 1313) |
| p = 0.02; n = 20 | p = 0.01; n = 30 | p = 0.15; n = 20 | |
| Urine lactulose/creatinine ratio (linear) | −0.27 (−22, 21) | 154 (−79, 388) | 121 (−86, 329) |
| p = 0.97; n = 11 | p = 0.17; n = 14 | p = 0.22; n = 14 | |
Linear models estimate the relationships between 12-week changes in the log-transformed microbial translocation biomarkers (regression predictor) and 12-week changes in the inflammatory biomarkers (regression outcome) using ordinary least squares regression, adjusted for baseline biomarker values. Model size represents number of paired observations. Bold values represent statistically significant findings.