Table 1.
Significant IPA function annotations (FAs) in both gF and gC
| Function | FA | gF | gC | ||||
|---|---|---|---|---|---|---|---|
| FET P-value | BH P-value | Genes | FET P-value | BH P-value | Genes | ||
| Chemotaxis | Chemotaxis of neurons | 0.025 | 0.18 | BDNF, GFRA1, RGS3 | 0.0037 | 0.17 | EPHB2, GFRA1, SEMA3A, SLIT2 |
| Formation | Formation of dendrites | 0.028 | 0.18 | ACHE, BCL11A, BDNF, CTNNA2, GRIN3A, NRG1, PRKG1, SGK1, SYNE1 | 0.035 | 0.22 | DAB1, DSCAM, KLF7, KNDC1, MAP2, NRG1, PPP1R9B, RAC2, SEMA3A |
| Organization | Microtubule dynamics | 0.030 | 0.18 | ACHE, ATXN10, BAX, BCL11A, BCL2, BDNF, BSN, CDH1, CNTN4, CNTNAP2, CTNNA2, CTNND2, CYP19A1, DISC1, EGFR, GDA, GRIN3A, GSN, IGF1R, KATNB1, MAPK8, NFIB, NRG1, PRKG1, PTPRM, RND1, SGK1, SLC18A3, SLIT1, SLIT3, SNCA, SYNE1, UHMK1 | 0.032 | 0.22 | ATXN2, BBS10, CDH4, CNTN4, DAB1, DCC, DSCAM, EPHB1, EPHB2, GPM6A, KLF7, KNDC1, LAMB1, LRRC7, MAP2, MBP, MTOR, NRG1, PCDH15, PLD1, POU3F1, PPP1R9B, PRICKLE2, PRKCA, PTPRM, RAC2, RIT2, RUFY3, SEMA3A, SLIT1, SLIT2, TNFRSF12A, TRPV4, VANG |
| Migration | Migration of GABAergic neurons | 0.012 | 0.18 | GFRA1, SLIT1 | 0.013 | 0.22 | GFRA1, SLIT1 |
For each general function, the specific FA is shown together with the corresponding FET P-value, the BH multiple-testing corrected P-value and the genes responsible for the enrichment signal in the FA. Individual genes that contribute to the enrichment of a particular FA in both gF and gC are in bold.