Table 2.
Top 25 IPA FAs for gC
| Function | FA | FET P-value | BH P-value | No. of genes | Genes |
|---|---|---|---|---|---|
| Synaptic depression | Synaptic depression | 2.9 × 10−6 | 0.0015 | 13 | ADCY5, ADCY8, CNR1, DRD5, EPHB1, EPHB2, GRM7, LRRC7, MTOR, PRKCA, RYR3, ST8SIA4, SYNJ1, (ITSN1) |
| LTD | LTD | 2.0 × 10−5 | 0.0052 | 11 | ADCY5, ADCY8, CNR1, DRD5, EPHB2, GRM7, LRRC7, MTOR, PRKCA, RYR3, ST8SIA4 |
| Guidance | Guidance of axons | 4.8 × 10−4 | 0.061 | 16 | ALCAM, ANK3, CDH4, CNTN4, DCC, EPHB1, EPHB2, ERBB4, EXT1, GLI3, KLF7, NFASC, PLXNA2, SEMA3A, SLIT1, SLIT2 |
| LTD | LTD of cells | 4.8 × 10−4 | 0.061 | 6 | ADCY5, CNR1, DRD5, PRKCA, RYR3, ST8SIA4 |
| LTD | LTD of brain cells | 7.2 × 10−4 | 0.075 | 5 | ADCY5, CNR1, PRKCA, RYR3, ST8SIA4 |
| LTD | LTD of neurons | 0.0013 | 0.11 | 5 | ADCY5, CNR1, DRD5, RYR3, ST8SIA4 |
| Assembly | Assembly of olfactory cilia | 0.0020 | 0.13 | 3 | BBS10, PCDH15, VANGL2 |
| LTD | LTD of corticostriatal neurons | 0.0023 | 0.13 | 2 | ADCY5, CNR1 |
| Positioning | Positioning of cholinergic neurons | 0.0023 | 0.13 | 2 | SLIT1, SLIT2 |
| Contact repulsion | Contact repulsion | 0.0034 | 0.17 | 3 | DCC, SEMA3A, SLIT2 |
| Chemotaxis | Chemotaxis of neurons | 0.0037 | 0.17 | 4 | EPHB2, GFRA1, SEMA3A, SLIT2 |
| Development | Development of optic chiasm | 0.0068 | 0.22 | 2 | SLIT1, SLIT2 |
| Size | Size of lateral cerebral ventricle | 0.0068 | 0.22 | 2 | ANK2, NRG1 (includes EG:112400) |
| Apoptosis | Apoptosis of sensory neurons | 0.0076 | 0.22 | 3 | CDKN2D, HIPK2, KLF7 |
| Metabolism | Fatty acid metabolism | 0.010 | 0.22 | 5 | DAB1, ERBB4, NRG1, SEMA3A, ST8SIA1 |
| Abnormal morphology | Abnormal morphology of nervous system | 0.013 | 0.22 | 2 | CNR1, UHRF1 |
| Formation | Formation of oligodendrocytes | 0.013 | 0.22 | 2 | ERBB4, NRG1 |
| Guidance | Guidance of thalamocortical axons | 0.013 | 0.22 | 2 | SLIT1, SLIT2 |
| Migration | Migration of GABAergic neurons | 0.013 | 0.22 | 2 | GFRA1, SLIT1 |
| Pathfinding | Pathfinding of axons | 0.013 | 0.22 | 2 | DCC, EXT1 |
| Chemotaxis | Chemotaxis of cells | 0.014 | 0.22 | 5 | EPHB2, FPR2, GFRA1, SEMA3A, SLIT2 |
| Development | Development of diencephalon | 0.014 | 0.22 | 3 | SIM2, SLIT1, SLIT2 |
| LTD | LTD of synapse | 0.018 | 0.22 | 3 | CNR1, GRM7, MTOR |
| Synthesis | Synthesis of fatty acid | 0.020 | 0.22 | 4 | DAB1, ERBB4, NRG1, SEMA3A |
| Synthesis | Synthesis of lipid | 0.020 | 0.22 | 6 | CNR1, DAB1, ERBB4, NRG1, SEMA3A, ST8SIA1 |
For each general function, the specific FA is shown together with its corresponding FET P-value, the BH multiple-testing corrected P-value, the number of genes and the symbols of the genes responsible for the enrichment signal in the FA. The functions and FAs that remained significant in the IPA analysis of the genes that passed the more stringent criteria are underlined. The gene(s) in parentheses are those that emerged from the more conservative analysis.