Table 3.
Top 25 IPA FAs for gF
| Function | FA | FET P-value | BH P-value | No. of genes | Genes |
|---|---|---|---|---|---|
| Synaptic fatigue | Synaptic fatigue of synapse | 0.0021 | 0.18 | 2 | BDNF, SYN3 |
| Apoptosis | Apoptosis of spinal cord cells | 0.0041 | 0.18 | 4 | BAX, BCL2, BDNF, FAM134B |
| Inhibition | Inhibition of neurons | 0.0053 | 0.18 | 4 | BDNF, NPPA, NPPB, NRG1 |
| Development | Development of sensory nervous system | 0.0062 | 0.18 | 2 | BDNF, KIF1A |
| Inhibition | Inhibition of pyramidal neurons | 0.0062 | 0.18 | 2 | BDNF, NRG1 |
| Concentration | Concentration of arachidonic acid | 0.0062 | 0.18 | 2 | DGKE, KNG1 |
| Endocytosis | Endocytosis of synaptic vesicles | 0.0067 | 0.18 | 4 | AMPH, CABIN1, ITSN1, SNCA |
| Damage | Damage of cortical neurons | 0.0067 | 0.18 | 3 | BAX, BDNF, GRIN3A |
| Quantity | Quantity of central nervous system cells | 0.0090 | 0.18 | 9 | ACHE, AVPR1B, CCND2, EGFR, GDA, IGFBP6, LEF1, LHX5, TSC1 |
| LTP | LTP | 0.0092 | 0.18 | 13 | B3GAT1, BDNF, CDH1, CHRNA7, CYP19A1, DGKE, LRP1, LRP8, NRG1, PLG, SNCA, VAV2, VAV3 |
| Apoptosis | Apoptosis of dorsal root ganglion cells | 0.0093 | 0.18 | 3 | BAX, BCL2, FAM134B |
| Mobilization | Mobilization of Ca2+ | 0.0093 | 0.18 | 3 | BDNF, PROK2, TRPV1 |
| Morphogenesis | Morphogenesis of neurites | 0.0097 | 0.18 | 22 | ACHE, ATXN10, BDNF, BSN, CNTN4, CNTNAP2, CTNNA2, CTNND2, CYP19A1, EGFR, GDA, IGF1R, MAPK8, NRG1, PRKG1, PTPRM, RND1, SGK1, SLC18A3, SLIT1, SYNE1, UHMK1, (TLR7) |
| Growth | Growth of dendrites | 0.0099 | 0.18 | 5 | BDNF, CTNND2, CYP19A1, NRG1, SLIT1 |
| Morphology | Morphology of dendrites | 0.0099 | 0.18 | 5 | BDNF, DISC1, GRIN2D, NPAS3, NRG1 |
| Quantity | Quantity of acetylcholine | 0.012 | 0.18 | 2 | ACHE, SLC18A3 |
| Survival | Survival of dorsal root ganglion | 0.012 | 0.18 | 2 | BAX, BDNF |
| Synaptogenesis | Synaptogenesis of brain cells | 0.012 | 0.18 | 2 | BDNF, CYP19A1 |
| LTP | LTP of granule cells | 0.012 | 0.18 | 2 | BDNF, DGKE |
| Sensitization | Sensitization of neurons | 0.012 | 0.18 | 2 | BDNF, KNG1 |
| Migration | Migration of GABAergic neurons | 0.012 | 0.18 | 2 | GFRA1, SLIT1 |
| Quantity | Quantity of astrocytes | 0.012 | 0.18 | 4 | ACHE, EGFR, IGFBP6, TSC1 |
| Cell viability | Cell viability of motor neurons | 0.015 | 0.18 | 5 | BAX, BCL2, BDNF, GFRA1, REG3G |
| Loss | Loss of motor neurons | 0.016 | 0.18 | 3 | BCL2, BDNF, GFRA1 |
| Quantity | Quantity of nerve ending | 0.016 | 0.18 | 3 | BDNF, SLC18A3, SNCA |
For each general function, the specific FA is shown together with the corresponding FET P-value, the BH multiple-testing corrected P-value, the number of genes and the symbols of the genes responsible for the enrichment signal in the FA. FAs that remained significant after excluding BDNF are in bold. The functions and FAs that remained significant in the IPA analysis of the genes that passed the more stringent criteria are underlined. The gene(s) in parentheses are those that emerged from the more conservative analysis.