Table 2.
Pairwise comparisons of geometric mean ratios of pharmacokinetic parameters between injection site groups
| Parameter | Injection sites compared | Ratios | |
|---|---|---|---|
| Point estimate | 90% CI | ||
| Cmax | Upper arm versus abdomen | 0.79 | 0.66–0.93 |
| Upper arm versus thigh | 0.90 | 0.76–1.06 | |
| Thigh versus abdomen | 0.88 | 0.74–1.04 | |
| AUC | Upper arm versus abdomen | 0.92 | 0.78–1.09 |
| Upper arm versus thigh | 1.09 | 0.93–1.28 | |
| Thigh versus abdomen | 0.84 | 0.72–0.99 | |
| AUClast | Upper arm versus abdomen | 0.92 | 0.77–1.08 |
| Upper arm versus thigh | 1.09 | 0.93–1.29 | |
| Thigh versus abdomen | 0.84 | 0.71–0.99 | |
AUC, area under the serum concentration versus curve from time zero to infinity (AUC); AUClast, area under the serum concentration versus curve from time zero to time of last concentration above lower limit of quantification; Cmax, maximum concentration; CI, confidence interval.