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a) ECG of normal group rats receiving only saline solution without pazopanib (PZP); b, c, d) ECG changes in rats receiving saline solution, metoprolol and diltiazem after 3 hours of PZP administration; b) QT prolongation in control group rats receiving only saline solution after PZP administration; c) QT-interval shortage in the PZP+metoprolol group; and d) QT-interval shortage in the PZP+diltiazem group. QT intervals are shown in the black areas.
