Table 1.
Effect of atenolol on hemodynamic variables in ovine hyperdynamic sepsis
| Cardiovascular variables | Gp | Baseline | Sepsis (8 h) | Sepsis (24 h) |
|---|---|---|---|---|
| CO (L/min) | A | 3.26 (2.80;3.79) | 4.01(3.40;4.73)† | 4.71 (3.99;5.55)§* |
| C | 3.35 2.88;3.90) | 4.13(3.50;4.86)† | 5.86 (4.97;6.90)§* | |
| HR (beats/min) | A | 68 (59;79) | 138 (116;163)† | 109 (92;129)§* |
| C | 68 (58;78) | 133 (113;158)† | 152 (128;180)§* | |
| SV (mL/beat) | A | 49.9 ± 4.3 | 30.4 ± 4.5† | 45.0 ± 4.5§* |
| C | 51.3 ± 4.3 | 34.2 ± 4.5* | 41.3 ± 4.5§* | |
| MAP (mmHg) | A | 95.4 ± 4.9 | 96.0 ± 5.1 | 77.2 ± 4.8§ |
| C | 93.7 ± 4.9 | 95.9 ± 5.1 | 83.2 ± 5.1§ | |
| TPC (L/min/mmHg) | A | 37.0 ± 4.2 | 44.2 ± 4.6† | 69.2 ± 4.6§ |
| C | 38.2 ± 4.4 | 45.0 ± 4.5† | 77.4 ± 4.6)§ | |
| RBF (mL/min) | A | 198 (169;238) | 268 (220;325)†* | 286 (236;348)§* |
| C | 212 (178;253) | 330 (233;400)†* | 335 (277;407)§* | |
| RVC (mL/min/mmHg) | A | 2.11 (1.78;2.50) | 2.81(2.31;3.41)† | 3.75 (3.09;4.55)§ |
| C | 2.32 (1.99;2.75) | 3.48(2.88;4.21)† | 3.51 (2.93;4.2)§ |
Measurements were taken during a 24-hour baseline, at 8 hours of sepsis (mean of 7th and 8th hour) and at 24 hours of sepsis (mean of 23rd and 24th hour) in a control group (C) and a group treated with atenolol from 8 to 24 hours of sepsis (A) (n = 8/group). Values are mean ± SEM for normally distributed or geometric mean (95% confidence interval) for non-normally distributed variables. † P ≤0.01 for baseline vs. 8 hours of sepsis; § P ≤0.01 for 8 hours of sepsis vs. 24 hours of sepsis; * P ≤0.01 for Aten vs. Con. CO: cardiac output; HR: heart rate; SV: stroke volume; MAP: mean arterial pressure; TPC: total peripheral conductance; RBF: renal blood flow; RVC: renal vascular conductance.