Table 2.
Effect of atenolol on oxygen variables in ovine hyperdynamic sepsis
| Biochemical variables | Gp | Baseline | Sepsis (8 h) | Sepsis (10 h) | Sepsis (12 h) | Sepsis (24 h) |
|---|---|---|---|---|---|---|
| pO2 (mmHg) | A | 90 ± 2 | 84 ± 2 | 86 ± 3 | 86 ± 3 | 77 ± 2 |
| C | 86 ± 3 | 78 ± 4 | 78 ± 4 | 79 ± 5 | 75 ± 6 | |
| SvcO2 (%) | A | 68.2 ± 2.9 | 72.3 ± 3.3 | 70.0 ± 2.2 | 69.4 ± 3.0 | 72.5 ± 3.9 |
| C | 54.6 ± 4.6 | 71.2 ± 1.7 | 67.3 ± 6.9 | 74.8 ± 3.6 | 72.9 ± 1.2 | |
| DO2 (mL O2/min) | A | 463 (400;536) | 561 (485;650) | 496 (427;577) | 513 (441;597) | 605 (522;700) |
| C | 489 (422;566) | 590 (502;692) | 597 (508;702) | 619 (527;728) | 706 (610;818)† | |
| VO2 (mL O2/min) | A | 167 ± 17 | 168 ± 17 | 136 ± 17 | 145 ± 17 | 142 ± 17 |
| C | 146 ± 17 | 144 ± 17 | 154 ± 19 | 154 ± 19 | 143 ± 17 | |
| O2 E (%) | A | 31.4 (24.2;40.3) | 27.9 (21.2;36.8) | 27.1 (20.7;35.5) | 27.3 (20.9; 35.7) | 19.3 (15;24.8) |
| C | 33.2 (25.9;42.7) | 24.1 (18.7;30.9) | 24.6 (18.4;32.8) | 23.8 (17.8;31.8) | 22.4 (17.4;28.8)† | |
| Lactate (mmol/L) | A | 0.37 (0.24;0.56) | 1.20 (0.79;1.83)† | 1.61 (1.05;2.49)† | 1.57 (1.02;2.41)† | 1.31 (0.86;1.99)† |
| C | 0.39 (0.26;0.59) | 1.37 (0.9;2.08)† | 1.54 (1.00;2.37)† | 1.55 (1.01;2.39)† | 1.34 (0.88;2.04)† |
Oxygen variables and arterial lactate during 24 hours of baseline and at 8, 10, 12 and 24 hours of sepsis in the control group (C) and the group treated with atenolol from 8 to 24 h of sepsis (n = 8/group). Values are mean ± SEM or geometric mean (95% confidence interval) for normally and non-normally distributed variables, respectively. † P ≤0.01 for time change vs. baseline (within group comparison). pO2: partial pressure of oxygen; SvcO2: superior vena cava O2 saturation; DO2: O2 delivery; VO2: O2 consumption; O2E: oxygen extraction ratio.