Table 3.
Renal effects of atenolol in ovine sepsis
| Renal variables | Gp | Baseline | Sepsis (8 h) | Sepsis (10 h) | Sepsis (12 h) | Sepsis (24 h) |
|---|---|---|---|---|---|---|
| Urine (mL/h) | A | 24.2 (17.3;33.7) | 19.7 (12.2;31.9) | 15.8 (9.8;25.6) | 10.6 (6.5;17.3) | 17.9 (11.0;29.0) |
| C | 22.2 (15.9;31.0) | 30.3 (18.5;49.5) | 21.2 (13.1;34.4) | 14.2 (8.8;23.0) | 14.7 (9.1;23.9) | |
| P-creat (μmol/L) | A | 73 (60;88) | 108 (90; 130)† | 123 (100;150)† | 138 (113;168)† | 158 (131;191)† |
| C | 62 (51;75) | 84 (70;101) | 90 (73;109) | 97 (79;118)† | 132 (110;160)† | |
| CreatCl (mL/min) | A | 58.5 ± 7.1 | 30.9 ± 7.0† | 26.5 ± 7.7† | 16.4 ± 7.7† | 36 ± 7.1 |
| C | 66.1 ± 7.1 | 43.4 ± 7.0† | 45.3 ± 7.7 | 37.5 ± 7.7† | 39.7 ± 7.1† | |
| FENa (%) | A | 0.21 (0.11;0.43) | 0.42 (0.21;0.85) | 0.32 (0.16;061) | 0.51 (0.26;0.98) | 0.13 (0.07:0.26) |
| C | 0.18 (0.09;0.39) | 0.48 (0.24;0.96) | 0.26 (0.14;0.50) | 0.20 (0.10;0.38) | 0.08 (0.04;0.15) | |
| FEK (%) | A | 29.7 ± 3.9 | 25.7 ± 3.9 | 26.3 ± 4.9 | 27.9 ± 4.9 | 27.2 ± 3.9 |
| C | 23.7 ± 3.9 | 25 ± 3.9 | 20.2 ± 4.9 | 18.0 ± 4.9 | 25.9 ± 3.9 | |
| FEUN (%) | A | 48.2 ± 7.6 | 35.9 ± 7.1 | 32.3 ± 7.2 | 31.2 ± 7.2 | 17.5 ± 7.1† |
| C | 47.9 ± 7.1 | 42.7 ± 7.1 | 31.5 ± 7.2 | 29.4 ± 7.2 | 22.0 ± 7.1† |
Renal function parameters during 24 hours of baseline and at 8, 10, 12 and 24 hours of sepsis in the control group (C) and the group treated with atenolol from 8 to 24 hours of sepsis (n = 8/group).Values are mean ± SEM or geometric mean (95% confidence interval) for normally and not-normally distributed variables, respectively. † P ≤0.01 for time change vs. baseline (within group comparison). P-creat: plasma creatinine; CreatCl: creatinine clearance; FENa: fractional excretion of sodium; FEK: fraction excretion of potassium; FEUN: fractional excretion of urea nitrogen. BP values: mean of 24-hour baseline period.