Table 1.
Demographic and clinical details of the sample at the time of the intervention a
| Variable | Baseline group (n = 19) | Intervention group (n = 33) | Femoral (n = 23) | Nonfemoral (n = 10) |
|---|---|---|---|---|
| Age, yr | 63.6 (13.6) | 63.7 (14.8) | 63.7 (14.1) | 63.6 (17.2) |
| Sex, % male | 79% | 61% | 65% | 50% |
| BMI | 28.0 (5.1) | 29.3 (10.6) | 31.7 (11.2) | 23.9 (7.0) |
| Diagnosis, % | ||||
| Cardiogenic shock/cardiac | 26% | 33% | 30% | 40% |
| Septic shock/sepsis/MOF | 47% | 43% | 44% | 40% |
| Renal/metabolic/electrolyte | 21% | 15% | 17% | 10% |
| Haemorrhagic shock/haematoma | 0% | 9% | 9% | 10% |
| Vascular surgery | 5% | 0% | 0% | 0% |
| APACHE II score | – | 26.1 (7.2) | 25.7 (6.8) | 26.9 (8.2) |
| APACHE III score | 98.3 (26.9) | 93.8 (24.9) | 91.1 (23.1) | 100.0 (29.1) |
| ICU length of stay, days | 10.2 (6.9) | 15.0 (10.0) | 15.4 (9.3) | 14.1 (11.8) |
| MV, % | 74% | 76% | 74% | 80% |
| MV hours, median (IQR) | 78 (0 to 153) | 76 (0 to 267) | 89 (0 to 295) | 63 (30 to 190) |
| Siteb, % | ||||
| Femoral | 63% | 70% | 100% | 0% |
| Internal jugular | 37% | 21% | 0% | 70% |
| Subclavian | 0% | 9% | 0% | 30% |
| Catheter typec, n (%) | ||||
| Dolphin Protect | 13 (68%) | 19 (58%) | 13 (57%) | 6 (55%) |
| Niagara™ | 5 (26%) | 9 (27%) | 7 (30%) | 2 (18%) |
| Arrow-Howes™ | 1 (5%) | 5 (15%) | 3 (13%) | 1 (9%) |
| Intervention filter type, % | ||||
| Prismaflex ST100 | N/A | 94% | 91% | 100% |
| Intervention filter anticoagulation, % | ||||
| Heparin | N/A | 27% | 26% | 30% |
| Citrate | N/A | 6% | 4% | 10% |
| Saline | N/A | 0% | 0% | 0% |
| Regional circuit | N/A | 52 | 48% | 60% |
| Other | N/A | 3% | 4% | 0% |
| Nil | N/A | 12% | 17% | 0% |
| FBE on intervention filter, median (IQR) | ||||
| Hb, g/dl | N/A | 89 (85 to 94) | 88 (81 to 91) | 93 (90 to 103) |
| Platelets, 103 U/L | N/A | 125 (60 to 200) | 121 (59 to 174) | 179 (60 to 252) |
| INR | N/A | 1.1 (1.1 to 1.4) | 1.2 (1.1 to 1.4) | 1.1 (1.1 to 1.3) |
| aPTT | N/A | 39 (34 to 52) | 40 (34 to 55) | 34 (33 to 44) |
| RASS, median (IQR) | N/A | -1 (-4 to 0) | -2 (-4 to 0) | -1 (-1 to 0) |
| CAM-ICU positive, % | N/A | 42% | 39% | 50% |
| Hospital LOS in days, median (IQR) | 23 (9 to 31) | 31 (21 to 57) | 29 (21 to 57) | 37 (15 to 57) |
| Hospital mortality, % | 42% | 15% | 17% | 10% |
aaPTT, Activated thromboplastin time; BMI: Body mass index; CAM-ICU: Confusion Assessment Method for the ICU; FBE: Full blood examination; Hb: Haemoglobin; ICU: Intensive care unit; INR: International normalized ratio; IQR: Interquartile range; LOS: Length of stay; MOF: Multiorgan failure; MV: Mechanical ventilation; N/A: Not applicable; RASS: Richmond Agitation–Sedation Scale. bFemoral (14 in right, 9 in left), intrajugular (6 in right, 1 in left) and subclavian (3 in left, 1 in right). cDolphin Protect (13-French gauge, 25 cm; Gambro, Hechingen, Germany), Niagara™ (13.5-French gauge; Bard Access Systems, Salt Lake City, UT, USA), Arrow-Howes™ triple-lumen (13-French, 20 cm; Teleflex, Research Triangle Park, NC, USA). Data are mean (SD) unless otherwise specified. Percentages may not add up to 100% due to rounding.