Table 3. Estimated adjusted regression coefficients relating maternal prenatal urinary phthalate concentrations to the WISC-IV full scale IQ and subscales at child age 7 years.
| Β-Coefficient (95% CI) | Child sex | ||||||||
| Total | Girls | Boys | Difference | ||||||
| Metabolite (log base e) | (n = 328) | (n = 173) | (n = 155) | p-value@ | |||||
| Full Scale | |||||||||
| MBnP | −2.69 | (−4.33,−1.05)** | −3.15 | (−5.44,−0.87)** | −1.89 | (−4.34, 0.56) | 0.46 | ||
| MBzP | −1.18 | (−2.40, 0.05) | −0.84 | (−2.52, 0.83) | −1.48 | (−3.35, 0.38) | 0.61 | ||
| MEHHP | 0.16 | (−1.16, 1.48) | 0.34 | (−1.35, 2.03) | 0.26 | (−1.87, 2.40) | 0.96 | ||
| MEHP | −0.30 | (−1.42, 0.82) | −0.05 | (−1.53, 1.42) | 0.09 | (−1.92, 2.11) | 0.74 | ||
| MEP | −0.17 | (−1.46, 1.13) | −0.75 | (−2.53, 1.03) | 0.40 | (−1.53, 2.33) | 0.39 | ||
| MiBP | −2.69 | (−4.22,−1.16)** | −2.38 | (−4.50,−0.26)* | −2.92 | (−5.17,−0.67)* | 0.73 | ||
| Perceptual Reasoning | |||||||||
| MnBP | −2.58 | (−4.40,−0.76)** | −3.55 | (−5.96,−1.14)** | −1.50 | (−4.36, 1.35) | 0.28 | ||
| MBzP | −1.65 | (−3.00,−0.30)* | −1.13 | (−2.89, 0.64) | −2.45 | (−4.60,−0.31)* | 0.35 | ||
| MEHHP | 0.18 | (−1.28, 1.64) | 0.03 | (−1.76, 1.82) | 0.56 | (−1.92, 3.04) | 0.73 | ||
| MEHP | −0.07 | (−1.30, 1.17) | −0.09 | (−1.65, 1.48) | 0.01 | (−2.00, 2.03) | 0.94 | ||
| MEP | −0.62 | (−2.05, 0.81) | −0.67 | (−2.56, 1.22) | −0.57 | (−2.81, 1.67) | 0.95 | ||
| MiBP | −2.41 | (−4.11,−0.71)* | −2.39 | (−4.64,−0.14)* | −2.41 | (−5.05, 0.23) | 0.99 | ||
| Processing Speed | |||||||||
| MnBP | −2.01 | (−3.91,−0.11)* | −1.29 | (−4.04, 1.45) | −2.85 | (−5.63,−0.08)* | 0.43 | ||
| MBzP | −0.47 | (−1.88, 0.95) | −0.74 | (−2.72, 1.23) | −0.02 | (−2.17, 2.12) | 0.63 | ||
| MEHHP | −0.41 | (−1.91, 1.10) | −0.84 | (−2.83, 1.15) | 0.25 | (−2.19, 2.68) | 0.50 | ||
| MEHP | −0.95 | (−2.23, 0.33) | −0.93 | (−2.67, 0.80) | −0.94 | (−2.92, 1.03) | 0.99 | ||
| MEP | 0.54 | (−0.95, 2.03) | −0.26 | (−2.37, 1.84) | 1.21 | (−0.99, 3.41) | 0.34 | ||
| MiBP | −1.94 | (−3.72,−0.17)* | −1.94 | (−4.46, 0.58) | −2.10 | (−4.70, 0.50) | 0.93 | ||
| Verbal Comprehensionn oCnsion | |||||||||
| MnBP | −1.52 | (−3.06, 0.02) | −1.06 | (−3.29, 1.16) | −1.64 | (−3.90, 0.62) | 0.72 | ||
| MBzP | −0.78 | (−1.92, 0.36) | −0.46 | (−2.06, 1.14) | −1.07 | (−2.79, 0.66) | 0.61 | ||
| MEHHP | 0.46 | (−0.76, 1.69) | 0.86 | (−0.75, 2.47) | 0.09 | (−1.88, 2.06) | 0.55 | ||
| MEHP | −0.28 | (−1.32, 0.76) | −0.01 | (−1.42, 1.40) | −0.60 | (−2.20, 1.00) | 0.58 | ||
| MEP | 0.10 | (−1.30, 1.11) | −0.71 | (−2.42, 0.99) | 0.52 | (−1.26, 2.31) | 0.32 | ||
| MiBP | −2.08 | (−3.51,−0.65)** | −1.05 | (−3.10, 1.00) | −3.04 | (−5.11,−0.98)** | 0.18 | ||
| Working Memory | |||||||||
| MnBP | −2.57 | (−4.55,−0.59)** | −4.73 | (−7.53,−1.93)** | −0.07 | (−2.92, 2.78) | 0.02 | ||
| MBzP | −0.68 | (−2.16, 0.80) | −0.59 | (−2.67, 1.48) | −0.50 | (−2.68, 1.67) | 0.95 | ||
| MEHHP | 0.36 | (−1.23, 1.94) | 1.16 | (−0.92, 3.25) | −0.29 | (−2.76, 2.18) | 0.37 | ||
| MEHP | 0.55 | (−0.79, 1.89) | 1.22 | (−0.60, 3.04) | 0.09 | (−1.92, 2.11) | 0.41 | ||
| MEP | −0.39 | (−1.95, 1.17) | −1.06 | (−3.26, 1.15) | 0.28 | (−1.96, 2.52) | 0.40 | ||
| MiBP | −1.98 | (−3.84,−0.12)* | −2.53 | (−5.16, 0.11) | −1.27 | (−3.92, 1.38) | 0.51 | ||
*p<0.05, **p≤0.01. @Wald Test.
Adjusted model for specific gravity, maternal IQ, ethnicity, alcohol use during pregnancy, education, marital status, total home score, and sex of child.