Table 11.
Adverse events
| Adverse events (AE) | Nitroxoline | Controls | |
|---|---|---|---|
| Patients (total) | 234 (100%) | 232 (100%) | |
| Patients with AEs# | 23 (9.8%) | 18 (7.8%) | |
| Adverse events (total) | 33 | 26 | |
| Nervous system disorders | Headache | 3 | 4 |
| Dizziness | - | 3 | |
| Eye disorders | Eyelid swelling | 1 | - |
| Cardiac and circulation disorders | Circulation disorder | - | 1 |
| Gastrointestinal disorders | Dysgeusia | - | 1 |
| Nausea | 9 | 3 | |
| Regurgitation | 1 | 1 | |
| Gastralgia | 4 | 3 | |
| Obstipation | - | 1 | |
| Diarrhoea | 5 | - | |
| Metabolim and nutrition disorder | Anorexia | 1 | - |
| Urinary disorders | Incontinence | 1 | - |
| Reproductive system disorders | Colpitis | 1 | 1 |
| Fluor vaginalis | 1 | - | |
| Tubal tumor | - | 1 | |
| Immune system disorders | Allergy | 1* | 1 |
| Skin and subcutaneous tissue disorders | Itching | 1 | 1 |
| Urticaria | 1 | 1 | |
| Herpes labialis | - | 1 | |
| General disorders | Intolerance | 1 | - |
| Weakness | 1 | - | |
| Fever | 1 | - | |
| Musculoskeletal, connective tissue and bone disorders | Back pain | - | 1 |
| Flank pain | - | 2 | |
| Leg pain | - | 1 |
#comparison of nitroxoline vs. controls (logistic regression with random center effect) p = 0.360; *with papules/pustules.