Table 6.
Demography, history, and physical parameters of female patients investigated in the safety set
| Nitroxoline | Controls | p-value | |||
|---|---|---|---|---|---|
| Demographic parameter | n | Median (range) | n | Median (range) | |
| Age (years) | 234 | 48 (18–89) | 232 | 47 (18–85) | 0.520 |
| -up to 45 years | 234 | 113 (48.3%) | 232 | 115 (49.6%) | 0.745 |
| Height (cm) | 234 | 165 (150–185) | 231 | 165 (145–187) | 0.290 |
| Weight (kg) | 234 | 62 (43–100) | 232 | 64 (42–102) | 0.125 |
| Body mass index (kg /m2) | 234 | 23.0 (15.9–41.3) | 231 | 23.2 (15.6–38.0) | 0.038 |
| Heart rate (min −1) | 231 | 80 (52–172) | 231 | 80 (56–120) | 0.354 |
| Systolic BP (mmHg) | 232 | 120 (80–195) | 231 | 130 (100–190) | 0.025 |
| Diastolic BP (mmHg) | 232 | 80 (60–120) | 231 | 80 (50–120) | 0.410 |
| No hypertension (SBP ≤ 140 mmHG) | 232 | 165 (71.1%) | 231 | 137 (59.3%) | 0.004 |
| Mild hypertension (SBP > 140 mmHG) | 232 | 46 (19.8%) | 231 | 63 (27.3%) | |
| Moderate hypertension (SBP > 160 mmHG) | 232 | 17 (7.3%) | 231 | 22 (9.5%) | |
| Severe hypertension (SBP > 180 mmHG) | 232 | 4 (1.7%) | 231 | 9 (3.9%) | |
| Diabetes mellitus | 234 | 11 (4.7%) | 232 | 6 (2.6%) | 0.230 |
| Duration of urinary symptoms (d) | 165 | 3 (1–30) | 168 | 3 (1–21) | 0.442 |
| Pretreatment with antimicrobials* | 234 | 16 (6.8%) | 232 | 8 (3.4%) | 0.060 |
| Only unspecific pretreatment# | 234 | 25 (10.7%) | 232 | 28 (12.1%) | 0.667 |
*antibiotics, chemotherapeutics.
#spasmolytics, analgetics, tea etc.