Table 2.
Sensitivity, specificity, predictive values and likelihood ratios of CRP and RNSOS as a single test and when in combination
| Sensitivity (C.I) | Specificity (C.I) | PPV (C.I) | NPV (C.I) | LHR + ve test (C.I) | LHR - ve test (C.I) | P value | |
|---|---|---|---|---|---|---|---|
| RNSOS | 65% (48 – 79.4) | 79.7% (72.9 – 85.5) | 43.3% (30.6 – 56.8) | 90.5% (84.6 – 94.7) | 3.24 (2.2 – 4.68) | 0.45 (0.28 – 0.64) | <0.01 |
| CRP1 | 87.5% (73.25 – 95.81) | 70.8% (63.3 – 77.58) | 41.7% (31 – 52.97) | 95.9% (90.84 – 98.68) | 3 (2.3 – 3.9) | 0.18 (0.08 – 0.4) | <0.01 |
| CRP2 | 78.9% (62.7 – 90.5) | 75.8% (68 – 81.7) | 42.3% (30.6 – 64.6) | 93.9% (88.5 – 97.3) | 3.2 (2.3 – 4.3) | 0.27 (0.15 – 4.3) | <0.01 |
| CRP 1 + CRP 2 | 75.7% (58.8 – 88.2) | 92.9% (87.9 – 96.2) | 70% (53.4 – 83.4) | 94.5 (89.9 – 97.4) | 10.6 (4.1 – 17.1) | 0.26 (0.10 – 0.42) | <0.01 |
| RNSOS + CRP 1 | 95.6% (90.0 – 97.5) | 56.4% (38.7 – 70.7) | 71% (51.9 – 85.7) | 89.8 (84.4 – 93.8) | 10.3 (2.7 –17.8) | 0.47 (0.3 – 0.65) | 0.01 |
| RNSOS + serial CRP | 47.5% (31.5 – 63.8) | 96.4% (92.4 – 98.7) | 76% (54.8 – 92.7) | 88.5% (83 – 92.7) | 13.3 (1.3 – 25.3) | 0.54 (0.37 – 0.72) | 0.03 |
C.I- confidence interval, CRP - C- reactive protein, RNSOS - Rubarth’s newborn scale of sepsis, PPV - Positive predictive value, NPV -negative predictive value, LHR - likelihood ratio.