Table 2.
Vaccine | Vaccine HA clade | Challenge virus HA clade | Challenge virus | Percent mortality | Mean death time | Number of chickens orally shedding 2DPC* |
---|---|---|---|---|---|---|
Sham | Not applicable | 2.2.1 | A/chicken/Egypt/959-NLQP/2006 | 100c | 2·3ab | 10/10 (100)a |
A/chicken/Egypt/13-NLQP/2008 | 100c | 2·4ab | 4/4 (100) | |||
A/goose/Egypt/20-NLQP/2009 | 100c | 3·2a | 10/10 (100)a | |||
A/duck/Egypt/44-NLQP/2009 | 100c | 2·1b | 2/2 (100) | |||
A/chicken/Egypt/2d -NLQP/2010 | 100c | 2·7ab | 10/10 (100)a | |||
2.2.1.1 | A/chicken/Egypt/202-NLQP/2007 | 100c | 2·1b | 1/1 (100) | ||
A/chicken/Egypt/65-NLQP/2008 | 100c | 2·6ab | 10/10 (100)a | |||
A/chicken/Egypt/63-NLQP/2010 | 100c | 2·3ab | 10/10 (100)a | |||
A/chicken/Mexico/232/1994 H5N2 | Classical H5 | 2.2.1 | A/chicken/Egypt/959-NLQP/2006 | 0a | – | 8/10 (80)a |
A/goose/Egypt/20-NLQP/2009 | 0a | – | 6/10 (60)a | |||
A/chicken/Egypt/2d-NLQP/2010 | 0a | – | 7/10 (70)a | |||
2.2.1.1 | A/chicken/Egypt/65-NLQP/2008 | 10a | 9·0 | 10/10 (100)a | ||
A/chicken/Egypt/63-NLQP/2010 | 10a | 8·0 | 10/10 (100)a | |||
Re-1 Goose/Guangdong/1996 H5N1 | 0 | 2.2.1 | A/chicken/Egypt/959-NLQP/2006 | 0a | – | 8/10 (80)ab |
A/chicken/Egypt/13-NLQP/2008 | 10a | 3·0 | 10/10 (100)a | |||
A/goose/Egypt/20-NLQP/2009 | 0a | – | 4/10 (40)b | |||
A/chicken/Egypt/2d-NLQP/2010 | 0a | – | 7/10 (70)ab | |||
A/duck/Egypt/44-NLQP/2009 | 0a | – | 8/10 (80)ab | |||
2.2.1.1 | A/chicken/Egypt/202-NLQP/2007 | 20ab | 6·0 | 9/10 (100)a | ||
A/chicken/Egypt/65-NLQP/2008 | 50b | 7·0 | 9/10 (90)a | |||
A/chicken/Egypt/63-NLQP/2010 | 40ab | 7·0 | 10/10 (100)a | |||
A/chicken/Egypt/13-NLQP/2008 H5N1 | 2.2.1 | 2.2.1 | A/chicken/Egypt/959-NLQP/2006 | 0a | – | 9/9 (100)a |
A/chicken/Egypt/13-NLQP/2008 | 0a | – | 9/10 (90)a | |||
A/goose/Egypt/20-NLQP/2009 | 0a | – | 2/10 (20)b | |||
A/duck/Egypt/44-NLQP/2009 | 10a | 6·0 | 10/10 (100)a | |||
2.2.1.1 | A/chicken/Egypt/202-NLQP/2007 | 20ab | 4·0 | 9/9 (100)a | ||
A/chicken/Egypt/65-NLQP/2008 | 0a | – | 7/8 (87·5)a | |||
A/chicken/Egypt/202-NLQP/2007 H5N1 | 2.2.1.1 | 2.2.1 | A/chicken/Egypt/959-NLQP/2006 | 0a | – | 8/8 (100)a |
A/chicken/Egypt/13-NLQP/2008 | 30ab | 2·7 | 9/10 (90)a | |||
A/goose/Egypt/20-NLQP/2009 | 0a | – | 1/9 (11·1)b | |||
A/duck/Egypt/44-NLQP/2009 | 70bc | 6·1 | 10/10 (100)a | |||
2.2.1.1 | A/chicken/Egypt/202-NLQP/2007 | 20ab | 3·5 | 10/10 (100)a | ||
A/chicken/Egypt/65-NLQP/2008 | 0a | – | 7/8 (87·5)a |
Superscript letters denote the statistical group within the same column (groups without superscripts were not included in statistical calculations due to inadequate sample numbers).
Number positive/total (% positive).