Figure 3. Fractional rates of muscle protein synthesis and protein degradation.

Fractional rates of muscle protein synthesis and protein degradation for pooled hind limb muscles from Control mice, mice undernourished from PN1 to PN11 (Early-UN) or PN11 to PN22 (Late-UN), or refed (RF) for 2 days, 7 days, 21 days or 18 months (synthesis rates only). Protein synthesis rate was measured in vivo using a flooding dose of l-[4-³H]-phenylalanine; protein degradation rate was calculated as the difference between fractional protein synthesis and growth rates. Values are least square means ± SEM; n = 7–8 litters per treatment group.*Significant difference between age-matched groups where age×group is significant.