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. 2014 Dec 10;9(12):e114106. doi: 10.1371/journal.pone.0114106

Table 2. pKa values and ΔHprot of compounds (14)b and the pKa values and ΔHprot of H2O bound to Zn in the active site of human recombinant CAs at 37°C.

Compound pKa(calculated) pKa(measured) ΔHprot,kJ/mol
1b 8.7 8.9 −24.3
2b 9.7 9.4 −29.7
3b 9.7 9.4 −29.7
4b 8.7 8.9 −24.3
CA
CAI-Zn-H2O 8.1a −38.5a
CAII-Zn-H2O 6.9a −23.5a
CAVII-Zn-H2O 6.8b −30.5b
CAXII-Zn-H2O 6.8c −25.5c
CAXIII-Zn-H2O 8.0d −41.5
a

from [37], bfrom [36], cfrom [35], dfrom [31].