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. 2014 Dec 10;9(12):e114106. doi: 10.1371/journal.pone.0114106

Table 4. Comparison of Kd (determined by ITC, FTSA) and IC50 (determined by SFA) of the compound 1b binding to five isoforms of human recombinant CAs.

Kd, nM (ITC) Kd, nM (TSA) IC50, nM (SFA)
CAI 2300 3100 5550
CAII 430 330 220
CAVII 660 710 830
CAXII 370 1300 1100
CAXIII 270 330 450

All three methods provided the same values within the error margin.