Table 1.
CHROMOSOME | START OF PEAKS | END OF PEAKS | FOLD ENRICHMENT | ENTREZ GENE ID | GENE SYMBOL | GENE NAME |
---|---|---|---|---|---|---|
chr7 | 132757191 | 132757492 | 38.659794 | 60504 | 1121r | interleukin 21 receptor |
chr3 | 89709374 | 89709685 | 37.668518 | 16194 | 116ra | interleukin 6 receptor, alpha |
chr6 | 122902489 | 122902814 | 37.181004 | 73149 | Clec4a3 | C-type lectin domain family 4, member a3 |
chr11 | 60955751 | 60956142 | 35.720745 | 57916 | Tnfrsf13b | tumor necrosis factor receptor superfamily, member 13b |
chrX | 13213539 | 13213888 | 33.61721 | 23890 | Gpr34 | G protein-coupled receptor 34 |
chr4 | 66504343 | 66504608 | 33.29038 | 21898 | Tlr4 | toll-like receptor 4 |
chr7 | 108112592 | 108113189 | 33.136967 | 233571 | P2ry6 | pyrimidinergic receptor P2Y, G-protein coupled, 6 |
chr18 | 35879188 | 35879366 | 32.216496 | 68545 | Ecscr | endothelial cell-specific Chemotaxis regulator |
chr4 | 149501529 | 149501774 | 30.927835 | 56485 | Slc2a5 | solute carrier family 2 (facilitated glucose transporter), member 5 |
chr3 | 30763607 | 30763924 | 30.746971 | 71862 | Gpr160 | G protein-coupled receptor 160 |
chr7 | 16829398 | 16829780 | 29.842648 | 319430 | C5ar2 | complement component 5a receptor 2 |
chr11 | 120818969 | 120819371 | 29.78236 | 80879 | Slc16a3 | solute carrier family 16 (monocarboxylicacid transporters), member 3 |
chr1 | 121972010 | 121972524 | 28.747026 | 170706 | Tmem37 | transmembrane protein 37 |
chr9 | 110948641 | 110949068 | 27.061855 | 17002 | Ltf | lactotransferrin |
chr9 | 116075399 | 116075615 | 26.661926 | 21813 | Tafbr2 | transforming growth factor, beta receptor II |
chr18 | 60966814 | 60967338 | 26.09944 | 16149 | Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) |
chr5 | 114094521 | 114094878 | 26.044493 | 14747 | Cmklr1 | chemokine-like receptor 1 |
chr7 | 135258809 | 135259228 | 25.773195 | 16409 | Itgam | integrin alpha M |
chr13 | 37488117 | 37488288 | 25.773195 | 17084 | Ly86 | lymphocyte antigen 86 |
chr3 | 106592873 | 106593332 | 25.472342 | 12508 | Cd53 | CD53 antigen |
chr16 | 38789019 | 38789447 | 25.28691 | 22268 | Upk1b | uroplakin 1B |
chr11 | 46280548 | 46280823 | 24.811836 | 171285 | Havcr2 | hepatitis A virus cellular receptor 2 |
chr6 | 40535749 | 40536059 | 24.257126 | 23845 | Clec5a | C-type lectin domain family 5, member a |
chr11 | 78799024 | 78799325 | 23.375689 | 16859 | Laals9 | lectin, galactose binding, soluble 9 |
chr13 | 103496918 | 103497108 | 22.680412 | 17079 | Cd180 | CD180 antigen |
chr3 | 105735367 | 105735926 | 22.315817 | 433638 | l830077J02Rik | RIKEN cDNA I830077J02 gene |
chr5 | 65352028 | 65352431 | 21.753523 | 21899 | Tlr6 | toll-like receptor 6 |
chr16 | 36642687 | 36643132 | 21.577559 | 12524 | Cd86 | CD86 antigen |
chr1 | 140026784 | 140027054 | 21.477663 | 19264 | Ptprc | protein tyrosine phosphatase, receptor type, C |
chr7 | 106859678 | 106859981 | 21.273113 | 101488 | Slco2b1 | solute carrier organic anion transporter family, member 2b1 |
chr6 | 122805926 | 122806252 | 20.940722 | 12267 | C3ar1 | complement component 3a receptor 1 |
chr7 | 16849252 | 16849697 | 20.837904 | 12273 | C5ar1 | complement component 5a receptor 1 |
chr4 | 132139773 | 132139985 | 20.618557 | 19204 | Ptafr | platelet-activating factor receptor |
chr19 | 40782595 | 40783023 | 20.34726 | 12495 | Entpd1 | ectonucleoside triphosphate diphosphohydrolase 1 |
chr11 | 69479440 | 69480081 | 20.306154 | 12514 | Cd68 | CD68 antigen |
chr1 | 172903138 | 172903598 | 20.071161 | 14130 | Fcar2b | Fc receptor, IgG, low affinity lIb |
chr10 | 19317003 | 19317223 | 19.63672 | 15979 | Ifngrl | interferon gamma receptor 1 |
chr3 | 87180536 | 87180918 | 19.435524 | 229499 | FcrM | Fc receptor-like 1 |
chr6 | 125030472 | 125030733 | 19.091257 | 381810 | Lpar5 | lysophosphatidic acid receptor 5 |
chr3 | 59064135 | 59064423 | 19.032515 | 70839 | P2ry12 | purinergic receptor P2Y, G-protein coupled 12 |
chr16 | 33947248 | 33947454 | 18.990776 | 16419 | Itab5 | integrin beta 5 |
chr1 | 172989424 | 172989659 | 18.93541 | 14131 | Fcar3 | Fc receptor, IgG, low affinity III |
chr4 | 133654539 | 133654895 | 18.744143 | 23833 | Cd52 | CD52 antigen |
chr7 | 4018702 | 4019029 | 18.126204 | 52855 | Lairl | leukocyte-associated lg-like receptor 1 |
chrX | 103346689 | 103346910 | 17.842981 | 279572 | TIr13 | toll-like receptor 13 |
chr9 | 119977884 | 119978196 | 17.774618 | 13051 | Cx3cr1 | chemokine (C-X3-C) receptor 1 |
chr1 | 174408269 | 174408572 | 17.634293 | 98365 | Slamf9 | SLAM family member 9 |
chr3 | 100835299 | 100835620 | 16.568483 | 630146 | Cd101 | CD101 antigen |
chr2 | 93289154 | 93289478 | 16.108248 | 12521 | Cd82 | CD82 antigen |
chr4 | 47408473 | 47408654 | 16.108248 | 21812 | Tgfbr1 | transforming growth factor, beta receptor I |
chr3 | 105716542 | 105717356 | 15.942183 | 11542 | Adora3 | adenosine A3 receptor |
chr15 | 103140748 | 103141572 | 14.66406 | 80910 | Gpr84 | G protein-coupled receptor 84 |
chr7 | 31198532 | 31198988 | 14.567458 | 22177 | Tyrobp | TYRO protein tyrosine kinase binding protein |
chr5 | 138278454 | 138278742 | 14.318442 | 231805 | Pilra | paired immunoglobin-like type 2 receptor alpha |
chr3 | 96097068 | 96098277 | 14.087213 | 14129 | Fcqrl | Fc receptor, IgG, high affinity I |
chr9 | 114661993 | 114662369 | 14.058106 | 67213 | Cmtm6 | CKLF-like MARVEL transmembrane domain containing 6 |
chr17 | 48491514 | 48491850 | 12.772557 | 83433 | Trem2 | triggering receptor expressed on myeloid cells 2 |
chr15 | 78135354 | 78135537 | 12.326311 | 12984 | Csf2rb2 | colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) |
chr18 | 61280165 | 61280583 | 10.698308 | 12978 | Csf1r | colony stimulating factor 1 receptor |
chr1 | 172948811 | 172949254 | 10.376222 | 246256 | Fcqr4 | Fc receptor, IgG, low affinity IV |
chr4 | 144830530 | 144830848 | 9.163803 | 21938 | Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1 b |
chr10 | 59834857 | 59835131 | 8.8232565 | 74048 | 4632428N05Rik | RIKEN cDNA 4632428N05 gene |
chr9 | 20820541 | 20820889 | 7.9916887 | 15894 | Icam1 | intercellular adhesion molecule 1 |
Notes: From the ChIP-Seq dataset, we identified 5,264 Spi1-target genes in BV2 mopuse microglia showing fold enrichment (FE) ≥5. Among them, those corresponding to microglial sensome genes (Supplementary Table 2) are listed with the chromosome, the position of the peak (start, end), FE, Entrez Gene ID, Gene Symbol, and Gene Name. The Cebpa-target genes are underlined.