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. 2014 Sep 19;9:207. doi: 10.1186/1748-717X-9-207

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© Helbig et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of BAY-87-2243 on tumor microenvironment and tumor growth. a) Pimonidazole hypoxic fraction (pHF), relative vascular area (RVA), fraction of perfused vessels (PF), and necrotic fraction (NF) in UT-SCC-5 tumors 24 h after end of treatment with BAY-87-2243 or carrier for 3, 5, or 7 days (n=7-9 tumors per time point and treatment group). b) Time to grow from 4 to 7 mm tumor diameter. UT-SCC-5 tumors were treated daily with BAY-87-2243 or carrier. Bars represent means ± SD of histological parameters or medians ± MAD (median absolute deviation) of growth times. Asterisks indicate significant differences from carrier control.